How does Benadryl injection interact with other medications?

Stacy Wiegman, PharmD

Pharmacy

Benadryl injection should not be taken with sodium oxybate (GHB). Benadryl injection may also interact with alcohol and muscle relaxants or sleep aids that may cause drowsiness. Discuss all medications and supplements with your doctor to be certain that diphenhydramine - Benadryl - will not cause an interaction. Read all over-the-counter drug labels, as some may contain diphenhydramine and cause an overdose.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.