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Factor 5 is a protein that is important for forming blood clots.
People usually have two copies of the Factor 5 gene. Sometimes the Factor 5 gene has a change in it called "Factor 5 Leiden." This change causes the protein to be overactive. An overactive Factor 5 protein increases the risk of forming blood clots too easily.
A person with one normal Factor 5 gene and one Factor 5 Leiden gene (we call this combination "heterozygous") has only a slight increased risk of a blood clot. A person with two Factor 5 Leiden genes (this combo is called "homozygous") has a much higher risk of clotting.
You asked about a person who has both genes for Factor 5 Leiden. In most cases, the mother and father of this person will each have one normal gene and one Factor 5 Leiden gene.
The brothers or sisters of this person might have:
This gives you some idea of the risks to family members. But the only way to know if each person has a risk is for them to be tested for the Factor 5 Leiden gene. Having one copy of the Factor 5 Leiden gene is not a big risk, so it makes sense to test only the people who are at risk of having two copies. To help you understand who should get tested, talk to a medical professional who is familiar with genetic testing, such as a genetic counselor or medical geneticist.
People usually have two copies of the Factor 5 gene. Sometimes the Factor 5 gene has a change in it called "Factor 5 Leiden." This change causes the protein to be overactive. An overactive Factor 5 protein increases the risk of forming blood clots too easily.
A person with one normal Factor 5 gene and one Factor 5 Leiden gene (we call this combination "heterozygous") has only a slight increased risk of a blood clot. A person with two Factor 5 Leiden genes (this combo is called "homozygous") has a much higher risk of clotting.
You asked about a person who has both genes for Factor 5 Leiden. In most cases, the mother and father of this person will each have one normal gene and one Factor 5 Leiden gene.
The brothers or sisters of this person might have:
- Two copies of the Factor 5 Leiden gene (a 25% chance)
- One copy like the parents (a 50% chance)
- Two normal Factor 5 genes (a 25% chance)
This gives you some idea of the risks to family members. But the only way to know if each person has a risk is for them to be tested for the Factor 5 Leiden gene. Having one copy of the Factor 5 Leiden gene is not a big risk, so it makes sense to test only the people who are at risk of having two copies. To help you understand who should get tested, talk to a medical professional who is familiar with genetic testing, such as a genetic counselor or medical geneticist.
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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.