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What medications interact with tumor necrosis factor inhibitors?

Donna Hill Howes, RN
Family Practitioner

If you are taking any of the following medications, TNF inhibitors can lead to side effects and should be avoided:

  • abatacept
  • anakinra
  • belimumab
  • canakinumab
  • natalizumab
  • pimecrolimus
  • rilonacept
  • roflumilast
  • tacrolimus
  • tocilizumab
  • tofacitinib
  • ustekinumab

If you are taking denosumab or leflunomide, a TNF inhibitor may not be a good option for you.

If you are taking etanercept, certolizumab and infliximab can lead to side effects and should be avoided.

If you are taking rituximab, certolizumab can lead to side effects and should be avoided.

If you are taking vedolizumab, adalimumab can lead to side effects and should be avoided.

There have been rare cases of T-cell lymphoma in people taking azathioprine and infliximab or mercaptopurine and infliximab.

If you take a TNF inhibitor, you should avoid echinacea.

If you are taking cyclophosphamide, etanercept can lead to side effects and should be avoided. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.