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Do thiopurines interact with any other medications?

Donna Hill Howes, RN
Family Practitioner

People taking thiopurines should avoid receiving live vaccines, such as the chicken pox or shingles vaccines. Other vaccines may not be effective.

If you are taking clozapine, mercaptopurine can lead to side effects and should be avoided.

If you are taking denosumab or leflunomide, a thiopurine may not be a good option for you.

If you are taking doxorubicin, mercaptopurine may not be a good option for you.

If you are taking febuxostat, natalizumab, pimecrolimus, or tacrolimus, thiopurines can lead to side effects and should be avoided.

There have been rare cases of T-cell lymphoma in people taking mercaptopurine and infliximab.

If you are taking tofacitinib, azathioprine can lead to side effects and should be avoided.

If you take azathioprine, you should avoid echinacea.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.