What causes granulomatosis with polyangiitis?

Sigma Nursing

Doctors and scientists do not yet know the cause of granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis. Some believe that the disease is caused by an infection that results in the characteristic inflamed blood vessels and harmful tissues (called granulomas). Others speculate that genetics or exposure to toxins causes the disease. Research into the cause of the condition is ongoing.

Continue Learning about Immune & Lymphatic System Disorders

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.

Immune & Lymphatic System Disorders

The lymphatic system is a key part of the immune system, draining excess fluid from bodily tissues and organs and disseminating white blood cells to fight infection. The white blood cells fight infection in the spleen and special vessels throughout the body called lymph nodes. If your immune system becomes compromised, the lymphatic system wont be able to work properly, causing swelling from a buildup of fluid in parts of the body. Disorders of the lymphatic system include elephantiasis, a swelling of body parts caused by a filarial worm infestation, and lymphedema, a swelling in the arms or legs caused by lymph nodes or lymph vessels disturbed by surgery for breast or prostate cancer. Medication, massage therapy and compression garments can help.

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