How do prokinetics treat gastroesophageal reflux disease (GERD)?

Lawrence S. Friedman, MD
Prokinetics -- or gastrokinetics, as they're occasionally called -- help empty the stomach of acids and fluids. They can also improve lower esophageal sphincter (LES) muscle tone. The LES is the muscle connecting the esophagus and stomach that acts as a barrier to protect the esophagus against the backflow of gastric acid from the stomach. These medications are used only for occasional cases of gastroesophageal reflux disease (GERD), either with or in place of H2 blockers, particularly when the stomach appears to empty slowly.

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