Genitourinary Agent

Recently Answered

• QWhat are rich sources of resveratrol?

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  A Dr. Michael Roizen, MD , Internal Medicine, answered

  Resveratrol, a nutrient found in red wine, offers many health benefits and even anti-aging benefits. But in order for a wine to have a significant amount of resveratrol, the skin of the grape must touch the seeds for at least three weeks. In many of today's wines, however, that time is less than a week—so not all wines are good sources of resveratrol.
  
  Another factor: The smaller the grape and the more seeds it has, and the cooler the climate it grows in, the more resveratrol it will have.
  
  Knotweed (a Japanese plant) has 40 times more resveratrol per pound than grapes do, and it grows everywhere (and makes a great apple pie). Paradoxically, muscadine grapes from the southeast United States also have a ton of resveratrol (several times more than wine).

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• QWhat are the side effects of Detrol LA?

  1 Answer

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  A Stacy Wiegman, PharmD , Pharmacy, answered

  The most common side effect of Detrol LA is dry mouth. Other common side effects may include one or more of the following:

  headache upset stomach constipation dry eyes blurred vision (difficulty focusing) dizziness/lightheadedness drowsiness bloody or discolored urine painful or burning urination, difficulty urinating

  Other less common side effects include abdominal cramping or pain, diarrhea, malaise, cough, runny nose, fever/chills, nausea, vomiting, indigestion (heartburn, belching), joint and muscle ache, achiness around the eyes and cheeks, anxiety, vertigo, difficulty sleeping, and weight gain. Some side effects will subside as your body adjusts to the medication. If you have persistent side effects or difficulty adjusting to any Detrol LA side effect, talk to your doctor. Talk to your doctor right away if you have chest pains, difficulty breathing, and/or shortness of breath.
  
  

• QIs there a generic version of Detrol LA?

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  A Stacy Wiegman, PharmD , Pharmacy, answered

  Currently, there is no generic form of Detrol LA. It is sometimes referred to by its generic name – tolterodine. However, a generic form of tolterodine is not yet available. 

   

• QAre there any risks in taking Detrol LA?

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  A Stacy Wiegman, PharmD , Pharmacy, answered

  There’s a risk for allergic reaction if you are allergic to one or more of the ingredients in Detrol LA, including tolterodine tartrate (active ingredient), sucrose, gelatin, dye, starch, and FD&C Blue #2. Allergic reaction may lead to

  -        swelling of the mouth, lips, tongue, face, ankles, feet, and hands;

  -        rash, hives, general itchiness;

  -        difficulty breathing, tightness in the chest, chest pain, irregular heartbeat;

  -        disorientation, memory problems, hallucinations, and confusion;

  -        vertigo, severe dizziness; and

  -        painful urination.

  There’s also a risk for adverse drug interaction with over-the-counter or prescription medications and supplements. To reduce the risk of serious drug interactions when taking Detrol LA, tell your doctor if you are taking dietary or herbal supplements, vitamins, and prescription medications. It’s especially important to tell your doctor if you are taking one or more of the following:

  -        clarithromycin (Biaxin)

  -        erythromycin (E-mycin, Ery-Tab)

  -        fluconazole (Diflucan)

  -        itraconazole (Sporanox)

  -        ketoconazole (Nizoral)

  Although Detrol LA is approved for use in adults, older adults do have an increased risk for kidney or liver problems in older adult, especially when taking higher doses of Detrol LA.

   

   

• QWho should take Detrol LA?

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  A Stacy Wiegman, PharmD , Pharmacy, answered

  To treat an overactive bladder, your doctor may prescribe Detrol LA once a day to prevent bladder contractions that lead to frequent, urgent urination. Detrol LA is an extended release capsule that should be taken as prescribed and at the same time each day. Dosage amounts will depend on your symptoms, age, and reaction to the medication.

   

• QWho should not take Detrol LA?

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  A Stacy Wiegman, PharmD , Pharmacy, answered

  Detrol LA is not for use in adults who have a slow emptying stomach, also known as gastric retention or slow emptying bladder known as urinary retention. Detrol LA is not used to treat overactive bladder in adults who have uncontrolled narrow-angle glaucoma. Adults should not take Detrol LA if they are allergic to any of its ingredients, including allergy to tolterodine tartrate (active ingredient), sucrose, gelatin, dye, starch, and FD&C Blue #2. Women who are pregnant or plan on becoming pregnant should not take Detrol LA until they have discussed the benefits and risks of Detrol LA with their doctor. Women who are breastfeeding should not take Detrol LA because it’s unclear whether the medication affects the breast milk. Detrol LA should not be used to children’s overactive bladder symptoms because of the risk of serious side effects to their health.

   

• QHow does Detrol LA interact with other medications?

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  A Stacy Wiegman, PharmD , Pharmacy, answered

  Detrol LA can react with other over-the-counter or prescription medications, resulting in more serious Detrol LA side effects. Detrol LA interaction with other medications such as antiarrhythmics (medications used to treat abnormal heart rhythm) can increase the risk for irregular heartbeats. Dosing restrictions may be needed if you are taking medications for yeast or bacterial infections as well. Detrol LA is sometimes prescribed with one or more of the following medications -  amiodarone, clarithromycin, cyclosporine, donepezil, erythromycin, fluconazole, fluoxetine, Galantamine, itraconazole, ketoconazole, miconazole, propafenone, quinidine, rivastigmine, tracrine, vinblastine, warfarin - which may increase Detrol LA side effects. To avoid drug interaction, it’s important to talk to your doctor about any and all medications or supplements you are taking and whether you smoke, have food allergies, or consume alcohol.

   

   

• QIs Detrol LA used to treat children's bed wetting symptoms?

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  A Stacy Wiegman, PharmD , Pharmacy, answered

  Detrol LA is not recommended for use in treating children’s bed wetting. Detrol LA affects children differently than adults with overactive bladder problems. If your doctor does prescribe Detrol LA for your child’s overactive bladder, its use and dose will differ from that prescribed for an adult.

   

• QWhat happens if I miss a dose of Detrol LA?

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  A Stacy Wiegman, PharmD , Pharmacy, answered

  If you miss a dose, take the dose as soon as you remember. Do not take the missed dose if it’s time for your next dose. Do not double the dose. Talk to your doctor if you’ve missed more than one dose.