Q

Genetic Disorders

What is Charcot-Marie-Tooth disease (CMT)?

A Answers (2)

  • CMT is a hereditary disease which affects the peripheral nerves (nerves in the hands and feet).  It typically begins in the teens and causes difficulty walking, poor balance, clumsiness, foot and hand deformities and numbness and weakness in the hands and feet.  It is a slowly progressive disease and does not alter a person's lifespan.
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  • A Cardiology (Cardiovascular Disease), answered on behalf of
    Charcot-Marie-Tooth (CMT) disease is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. The disease is named after the three physicians who first identified it in 1886 ― Jean-Martin Charcot and Pierre Marie in Paris, France, and Howard Henry Tooth in Cambridge, England. CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, consists of a group of disorders that affect the peripheral nerves. The peripheral nerves lie outside the brain and the spinal cord and supply the muscles and sensory organs in the limbs. The disorders that affect the peripheral nerves are called peripheral neuropathies.
    This answer is based upon source information from the National Institute of Neurological Disorders and Stroke.
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