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What is sulfasalazine?

Donna Hill Howes, RN
Family Practitioner

Sulfasalazine (Azulfidine) is a disease-modifying antirheumatic drug (DMARD) that helps reduce inflammation and affects the immune system. It is taken as daily tablets for the treatment of rheumatoid arthritis (RA). Sulfasalazine may be given to people who can't take methotrexate due to side effects or a lack of improvement. It is often used as a second DMARD for people who already take methotrexate or hydroxychloroquine, or a third DMARD for people who already take methotrexate and hydroxychloroquine.

It is sometimes used for treating psoriatic arthritis, but is not FDA approved for this use. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.