Which hormones affect my appetite?

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Ozgen Dogan
Cardiology (Cardiovascular Disease)
The hormone ghrelin is secreted by the stomach and is thought to signal hunger to the brain. The hormone leptin is secreted from fat cells. When it gets to a certain level, the feeling of fullness kicks in. One of the reasons sleepless people gain weight is because insomnia causes ghrelin levels to rise and leptin to fall. Strangely, leptin levels are higher in overweight people and lower in thin people. It's thought that obese people have developed a resistance to leptin, making its appetite-suppressing effects ineffective. Obestatin is a recently found hormone that acts as an appetite suppressant. All three of these hormones affect the hunger and fullness center in the part of our brain called the hypothalamus.
Dr. Michael Roizen, MD
Internal Medicine
In the last fifteen years, we've learned a lot about the hormonal influences. At least one of these was discovered accidentally, gherlin, a hormone secreted by the stomach that increases appetite. We learned of the importance of gherlin only by studying people who have had stomach bypass surgery for obesity (bariatric surgery). When you remove part of the stomach, you decrease gherlin levels, which in turn decreases the desire to eat. Other hormonal influences, such as leptin that has a role in regulating hunger by secretion in relation to its fat supply have also been uncovered.
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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.