What are the possible side effects of H.P. Acthar Gel?

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Possible side effects of H.P. Acthar Gel, a drug given by injection to treat many different conditions, include the following:
  • increased fluid retention
  • changes in how your body manages blood sugar
  • high blood pressure
  • increased appetite
  • weight gain
  • trouble sleeping
  • mental health symptoms, including mood swings, euphoria, depression, personality changes and psychosis
  • increased risk for eye problems, including infections, cataracts and glaucoma
  • increased susceptibility to infection (especially in young children on the medicine) 
  • growth problems in children
  • weakened bones 
  • symptoms of Cushing's syndrome, a hormonal disorder caused by prolonged exposure to cortisol, including round face, increased upper body fat, increased fat around the neck, thin skin and stretch marks, and weakened muscles