What should I know about spironolactone-hydrocholorothiazide?

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Before taking spironolactone-hydrocholorothiazide, you should talk to your doctor about medications and conditions that may interact with it. These include aspirin, captopril and other heart medications; arthritis, diabetes, and blood pressure medications; potassium supplements, and vitamins. Relevant items from your medical history include diabetes, gout, and kidney or liver disease. You should be aware that spironolactone-hydrocholorothiazide can make you drowsy and may be dangerous in combination with alcohol.