What are the side effects of chlorthalidone?

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If you experience signs of a serious allergic reaction such as hives; breathing difficulty; or swelling of the face, lips, tongue, or throat, get immediate emergency help, call 911. Serious side effects of the diuretic chlorthalidone include:

  • thirst
  • dry mouth
  • dark urine
  • inability to urinate, urinating less than normal or clay-colored stools
  • feeling lightheaded, drowsy, weak, or restless
  • stomach pain, nausea, vomiting, or loss of appetite
  • rapid or irregular heartbeat
  • muscle weakness or pain
  • bruising or bleeding easily
  • unusual weakness
  • spots on the skin that are purple or red
  • tingling or numbness
  • or jaundice (yellowed skin or whites of the eyes)

Contact your doctor right away if you have any of these symptoms.

Less serious side effects of chlorthalidone include diarrhea, constipation, lost appetite, headache, dizziness, or muscle spasms. Chlorthalidone may make your skin more sensitive to the sun and you may burn more easily; so take precautions. Not all side effects of this high blood pressure medication have been reported; so inform your doctor about any side effects you are experiencing.