Does hydrochlorothiazide interact with other medications or food?

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If you take the following medications while taking hydrochlorothiazide (HCTZ) capsules, you will have an increased risk of developing an irregular heartbeat: digoxin, dofetilide and ketanserin. Tell your doctor if you are taking barbiturates, corticotropin, corticosteroids, narcotics, cholestyramine, colestipol, nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, diazoxide or lithium. People taking insulin or oral medications for diabetes should know that the medicine's effectiveness may be decreased while taking hydrochlorothiazide.