How does Aldactone interact with other medications or foods?

Aldactone (spironolactone) may interact with many other medications. These medications include: potassium supplements, Midamor (amiloride), Dyrenium (triamterene), angiotensin-converting enzyme (ACE) inhibitors, such as Accupril (quinapril), Aceon (perindopril), Altace (ramipril), Capoten (captopril), Lotensin (benazepril), Mavik (trandolapril), Monopril (fosinopril), Prinivil (lisinopril), Univasc (moexipril), Vasotec (enalapril) and Zestril (lisinopril).

Aldactone may interact with aspirin or nonprescription or prescription nonsteroidal anti-inflammatory medications (NSAIDS), such as Advil or Motrin (ibuprofen), Indocin (indomethacin) or Aleve or Naprosyn (naproxen).

Other medications that may cause interactions include: other drugs for high blood pressure, narcotic pain drugs, diuretics, barbiturates, such as phenobarbital, and digoxin drugs, such as Digitek, Lanoxicaps or Lanoxin. Oral corticosteroids, such as Decadron or Dexone (dexamethasone), Deltasone (prednisone) or Medrol (methylprednisolone) may also interact with Aldactone.

While taking Aldactone, avoid salt substitutes that contain potassium. Your doctor may advise you to limit your intake of high-potassium foods, such as orange juice, bananas, raisins and prunes. You may also be directed to avoid drinking alcohol, as it can worsen certain side effects.