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Do thiazide diuretics interact with other medications?

Donna Hill Howes, RN
Family Practitioner

If you are taking digoxin or a loop diuretic, a thiazide diuretic may not be a good option for you.

If you are taking dofetilide, you should not take a thiazide diuretic.

If you are taking an ACE inhibitor, a thiazide diuretic may not be a good option for you.

If you are taking carbamazepine, cyclophosphamide, diazoxide, digoxin, an opioid, or oxcarbazepine, a thiazide diuretic may not be a good option for you. 

If you are taking a QTc interval prolonging drug, calcium channel blockers can lead to serious side effects.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.