What are gliptins?

Dr. Darria Long Gillespie, MD
Emergency Medicine
Gliptins, also called DPP-4 inhibitors, raise the level of the hormone incretin. This increases insulin and lowers glucagon. The overall effect is that more glucose is absorbed by cells and less glucose is produced in the liver. Gliptins are taken by mouth. They may be prescribed alone or in combination with other diabetes drugs.

Several gliptins are available in the US. These include alogliptin (Nesina), linagliptin (Tradjenta), saxagliptin (Onglyza), and sitagliptin (Januvia). Some other products combine a gliptin with another diabetes drug in a single pill, such as Glyxambi, Janumet, Jentadueto, Kazano, Kombiglyze XR, and Oseni.

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Continue Learning about Diabetes


Diabetes mellitus (MEL-ih-tus), often referred to as diabetes, is characterized by high blood glucose (sugar) levels that result from the body’s inability to produce enough insulin and/or effectively utilize the insulin. Diabetes ...

is a serious, life-long condition and the sixth leading cause of death in the United States. Diabetes is a disorder of metabolism (the body's way of digesting food and converting it into energy). There are three forms of diabetes. Type 1 diabetes is an autoimmune disease that accounts for five- to 10-percent of all diagnosed cases of diabetes. Type 2 diabetes may account for 90- to 95-percent of all diagnosed cases. The third type of diabetes occurs in pregnancy and is referred to as gestational diabetes. Left untreated, gestational diabetes can cause health issues for pregnant women and their babies. People with diabetes can take preventive steps to control this disease and decrease the risk of further complications.

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