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What are gliptins?

Donna Hill Howes, RN
Family Practitioner

Gliptins, also called DPP-4 inhibitors, raise the level of the hormone incretin. This increases insulin and lowers glucagon. The overall effect is that more glucose is absorbed by cells and less glucose is produced in the liver. Gliptins are taken by mouth. They may be prescribed alone or in combination with other diabetes drugs.

Several gliptins are available in the US. These include alogliptin (Nesina), linagliptin (Tradjenta), saxagliptin (Onglyza), and sitagliptin (Januvia). Some other products combine a gliptin with another diabetes drug in a single pill, such as Glyxambi, Janumet, Jentadueto, Kazano, Kombiglyze XR, and Oseni.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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