What are gliptins?

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Dr. Darria Long Gillespie, MD
Emergency Medicine
Gliptins, also called DPP-4 inhibitors, raise the level of the hormone incretin. This increases insulin and lowers glucagon. The overall effect is that more glucose is absorbed by cells and less glucose is produced in the liver. Gliptins are taken by mouth. They may be prescribed alone or in combination with other diabetes drugs.

Several gliptins are available in the US. These include alogliptin (Nesina), linagliptin (Tradjenta), saxagliptin (Onglyza), and sitagliptin (Januvia). Some other products combine a gliptin with another diabetes drug in a single pill, such as Glyxambi, Janumet, Jentadueto, Kazano, Kombiglyze XR, and Oseni.

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