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Do the main types of cutaneous T-cell lymphoma act differently?

The two main types of cutaneous T-cell lymphoma, mycosis fungoides and Sezary syndrome, behave differently. Mycosis fungoides is usually a slow-growing tumor. It generally occurs as distinct skin lesions that enlarge very slowly. These lesions sometimes remain the same size for years and they may even vanish spontaneously.

By contrast, Sezary syndrome is a much faster growing cancer. Individuals with the disease usually have a much greater amount of skin involvement, plus a higher likelihood of lymphoma cells spreading to the blood, lymph nodes, bone marrow, and distant organs. Because of this, the life expectancy is significantly lower with Sezary syndrome.

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