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What are the possible side effects of Harvoni?

Harvoni (ledipasvir and sofosbuvir) appears to have few side effects. In clinical trials, the most common adverse reactions were fatigue and headache. Some people also reported nausea, diarrhea and insomnia. Fewer than 1% of people stopped taking Harvoni because of these problems. However, Harvoni can interact with other medications, and in some cases this can worsen the side effects caused by those drugs. For example, Harvoni can raise the levels of rosuvastatin (Crestor) in the blood, increasing the risk of muscle pain and damage. This, in turn, can lead to liver and kidney problems.

While you are taking Harvoni, if you develop any side effects that concern you or don't go away, be sure to tell your doctor. 

Headache (17%), fatigue (18%), and diarrhea (<10%) are the most common side effects.

Donna Hill Howes, RN
Family Practitioner

Side effects of Harvoni may include fatigue, headache, insomnia, nausea, and diarrhea.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.