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What other medications do phenothiazines interact with?

Donna Hill Howes, RN
Family Practitioner

If you are taking any of the following drugs, phenothiazines can lead to side effects and should be avoided:

  • abiraterone
  • an anticholinergic drug
  • an anti-Parkinson drug
  • azelastine nasal spray
  • dronedarone
  • orphenadrine
  • paraldehyde
  • potassium chloride
  • phenothiazines

If you are taking any of these drugs, a phenothiazine may not be a good option for you:

  • a central nervous system depressant
  • lithium
  • methylphenidate
  • metyrosine
  • mirabegron
  • an opioid
  • rufinamide
  • a selective serotonin reuptake inhibitor
  • tetrabenazine
  • topiramate

If you are taking metoclopramide, you should avoid phenothiazines. If you are taking another cholinesterase inhibitor, phenothiazines may not be good options for you.

If you are taking a CYP2D6 inhibitor, thioridazine can lead to side effects and should be avoided. If you are taking abiraterone, chlorpromazine can lead to side effects and should be avoided.

If you are taking deferoxamine or dofetilide, prochlorperazine can lead to side effects and should be avoided.

If you are taking desmopressin, chlorpromazine may not be a good option for you.

If you are taking doxorubicin, pimozide, or tamoxifen, thioridazine can lead to side effects and should be avoided.

If you are taking ivabradine or mifepristone, thioridazine and chlorpromazine can lead to side effects and should be avoided.

If you are taking a drug that prolongs the QTc interval, phenothiazines can lead to serious side effects.

If you are taking metoprolol, thioridazine and chlorpromazine may not be good options for you.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.