Geodon (ziprasidone) can potentially interact with several medications, so it is important to talk with your doctor or pharmacist about all medications you are currently taking as well as any you may begin while taking Geodon.
Medications that may potentially interact with Geodon include: alfuzosin, amoxapine, apomorphine, carbamazepine, chloroquine, clozapine, cyclobenzaprine, dasatinib, droperidol, haloperidol, maprotiline, methadone, octreotide, olanzapine, ondansetron, paliperidone, palonosetron, pentamidine, pimozide, ranolazine, risperidone, sunitinib, tacrolimus, vardenafil, and vorinostat.
You need to discuss the use of anesthetics, antibiotics, antidepressants, HIV protease inhibitors, antifungal medications and certain arrhythmia medications with your doctor. Also, report all medications that include phenothiazine.
Discuss all medications you require for anxiety, elevated blood pressure or seizures, as these may need to be closely monitored or adjusted while taking Geodon. Most of the medications that interact with Geodon do so because they have similar components in them that increase the likelihood of heart arrhythmias, or irregular heartbeats. These also may be referred to as QT prolongation. Certain QT prolonging medications may be used with Geodon as long as the dosage of each medication is closely monitored.
Two medications, carbamazepine and ketoconazole (a fungal treatment), may actually cause the amount of Geodon in the blood to go higher or lower than intended by your doctor. If you are taking either of these medications you may require special dosing instructions. When discussing your diet with your doctor you should mention if you eat grapefruit or drink grapefruit juice on a regular basis. Juices in grapefruit have been known to interact with certain components of Geodon. Also, discuss all alcohol consumption as alcohol can interact with Geodon, magnifying the intensity of certain side effects.