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Can Pylera interact with other medications or foods?

Pylera, a medication used to treat peptic ulcers, can interact with several medications, as well as with foods or drinks containing calcium, alcohol or the additive propylene glycol. Tell your doctor about any prescription or over-the-counter medicines or supplements you are taking, especially:
  • disulfiram (Antabuse)
  • penicillin
  • certain anticoagulants such as warfarin (Coumadin, Jantoven)
  • cimetidine (Tagamet)
  • lithium (Eskalith, Lithobid)
  • phenobarbital (Luminal)
  • phenytoin (Dilantin, Phenytek)
  • probenecid (Col-probenecid, Probalan)
  • sulfinpyrazone
  • diabetes medications
Your doctor may want to discontinue or change the dosage of these medications before you begin taking Pylera, a combination of drugs used to treat peptic ulcers.

Pylera can also decrease the effectiveness of hormonal contraceptives, such as birth control pills, patches, rings, implants, injections and some intrauterine devices (IUDs), so you should use another form of birth control while taking Pylera. (Because of this interaction, you may also experience breakthrough bleeding if you take Pylera while using a hormonal contraceptive.)

If you need to use an antacid containing aluminum, calcium, magnesium or sodium bicarbonate, or a zinc supplement, be sure to take it one to two hours before or one to two hours after your dose of Pylera. Foods that contain calcium (such as dairy products and calcium-fortified foods and juices) should be eaten at least two hours before or one hour after Pylera. Iron supplements should be taken at least three hours before or two hours after.

You should also avoid beverages and products with alcohol or propylene glycol while taking Pylera and for at least three days after finishing your treatment. Alcohol and propylene glycol can cause nausea, vomiting, stomach cramps, headache, sweating and redness of the face when taken along with metronidazole, one of the antibiotics used in Pylera.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.