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What should I know about alosetron hydrochloride before taking it?

Alosetron hydrochloride is only intended for women with severe diarrhea-predominant irritable bowel syndrome (IBS). Women should only take this medication if other IBS medications to treat diarrhea have failed. A doctor must be specially trained in alosetron hydrochloride to prescribe this medication. You should be aware of the serious, though not common, risks involved in taking this drug. Some people have developed ischemic colitis and severe constipation while taking alosetron hydrochloride, leading to hospitalization and even death. You should call your doctor and stop taking this medication at the first sign of constipation.You will also need to discuss with your doctor if you have a history of severe or ongoing constipation, obstruction or perforation of your intestines, Crohn's disease, ulcerative colitis, diverticulitis, blood clots or circulation problems affecting your intestines, or severe liver disease.

Your doctor should be aware of all medications you are currently taking, including prescriptions, over-the-counter medications, and supplements. You cannot take alosetron hydrochloride while taking fluvoxamine for obsessive compulsive disorder. Other medications that may interact with alosetron hydrochloride include fluvoxamine, cimetidine, ketoconazole, itraconazole, voriconazole, isoniazid, hydralazine, procainamide, clarithromycin or telithromycin, HIV medicines, some antibiotics, and tricyclic antidepressants.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.