What are the side effects of SSNRIs in people with multiple sclerosis (MS)?

Selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) include Effexor (venlafaxine) and Cymbalta (duloxetine). Data suggests that these products may be more effective in treating multiple sclerosis (MS)-related severe depression and depression resistant to other medications than the selective serotonin reuptake inhibitors (SSRI) antidepressants and tricyclic antidepressants.

The most common adverse effects associated with SSNRIs include changes in appetite, weight and sleep; drowsiness, dizziness, fatigue, headache, nausea and vomiting, and sexual dysfunction. Generally, sexual dysfunction is milder with the SSNRIs compared to the SSRIs.

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