What are the possible side effects of Parnate?

The most common side effects of the antidepressant Parnate (tranylcypromine) include:
  • dizziness, lightheadedness or fainting if you get up too quickly after sitting or lying down
  • weakness
  • dry mouth
  • loss of appetite
  • diarrhea, constipation or stomach pain
  • blurred vision or ringing in your ears
  • chills
  • muscle tightening or jerking or uncontrollable shaking of a body part
  • numbness, burning or tingling in your arms or legs
  • trouble urinating
  • sexual problems
  • hair loss
  • rash
Parnate can also bring on a sudden surge in blood pressure, a potentially deadly side effect called hypertensive crisis. Symptoms of hypertensive crisis are headache; chest pain or tightness; unusually fast, slow or irregular heartbeat; a stiff or sore neck; nausea or vomiting; sweating (sometimes along with fever and/or cold, clammy skin); throat tightening; widened pupils; and sensitivity to light. Other potentially serious side effects of Parnate include swelling of arms, hands, feet, ankles or lower legs; unusual bleeding or bruising; pain in the upper right part of the stomach; and yellowing of skin or eyes.

Parnate may worsen depression or cause you to have new or stronger thoughts of harming or killing yourself. The risk of this side effect is highest for people under 25; it also can increase after a change in dosage. Symptoms to watch out for include agitation, anxiety, panic attacks, difficulty falling or staying asleep, irritability, hostility, aggressiveness, impulsivity, severe restlessness, mild mania, frenzied abnormal excitement or other behavioral changes.   

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.