How is duloxetine used to treat osteoarthritis?

Dr. Darria Long Gillespie, MD
Emergency Medicine
Duloxetine (Cymbalta) is a drug that was developed to treat depression. It is also FDA-approved to treat chronic musculoskeletal pain, such as osteoarthritis pain. Some treatment guidelines for osteoarthritis recommend it as an alternative to opioids for people who have tried other treatments but still have symptoms, and who can't or don't want to have surgery. 

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