Can Effexor interact with other medications or foods?

While there are no known food interactions with Effexor (venlafaxine), this prescription antidepressant interacts with a number of drugs and supplements.

Effexor should never be taken with monoamine oxidase inhibitors (MAOIs), an older class of antidepressant that includes Marplan (isocarboxazid), Nardil (phenelzine) and Parnate (tranylcypromine). The combination of Effexor and MAOIs can be dangerous, and even fatal.

Because Effexor affects the brain chemical serotonin, this drug may interact with other medications that affect serotonin, including triptans, a class of drugs prescribed to treat migraine headaches. If you take a triptan drug, you may be able to take Effexor, but your doctor will monitor you carefully.

In large amounts, tryptophan, a building block for the production of serotonin, may also interact with Effexor, so you should not take tryptophan supplements while on Effexor.

Be sure to give your doctor a list of all prescription and over-the-counter drugs and supplements you take before starting treatment with Effexor. If you have any questions about potential interactions, just ask your doctor or pharmacist.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.