What should I know about Nefazodone before taking it?

Talk to your doctor about your medical history, including a complete list of medications (prescription, herbal, over-the-counter, and supplements) before beginning Nefazodone treatment. Tell your doctor if you have liver disease, high transaminase blood levels, stomach bleeding, suicidal tendency, or any allergies. Before taking Nefazodone, tell your doctor if you are pregnant, may become pregnant, or are breastfeeding.

Nefazodone may interact with the following medications, leading to increased sedation: H1 antagonists (diphenhydramine), MAO inhibitors (phenelzine), HIV protease inhibitors (ritonavir), or tramadol. Nefazodone may increase the side effects of the following medications: benzodiazepines (alprazolam), corticosteroids (hydrocortisone), aldosterone blockers (spironolactone), buspirone, carbamazepine, eletriptan, cyclosporine, H1 antagonists (diphenhydramine), triazolam, HMG-CoA reductase inhibitors (simvastatin), MAO inhibitors (phenelzine), tramadol, or pimozide (Orap). The effectiveness of the anticoagulant warfarin (Coumadin) may decrease when used together with Nefazodone.

Be sure you tell your doctor if you are taking antihistamines, muscle relaxants, sleeping pills, sedatives, thyroid medications, tranquilizers, an MAO inhibitor, or medication for high blood pressure, Parkinson's disease, colds, seizures, allergies, or asthma within two weeks of beginning Nefazodone treatment. Tell your doctor if you are taking any of the following medications: alprazolam (Xanax), carbamazepine (Tegretol), buspirone (Buspar), cyclosporine (Neoral, Sandimmune), cimetidine (Tagamet), digoxin (Lanoxin), levodopa (Sinemet, Larodopa), haloperidol (Haldol), methylphenidate (Ritalin), propranolol (Inderal), tacrolimus (Prograf), and triazolam (Halcion). You may have to wait a brief period before taking Nefazodone if you recently stopped taking fluoxetine (Prozac, Sarafem). Before surgery or dental procedures, tell your doctor or dentist that you are taking Nefazodone.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.