Who should not take primidone?

Anyone who is allergic to the drug phenobarbital should not take primidone because primidone is broken down in the body to phenobarbital and another substance, abbreviated PEMA. Also, you should not take primidone if you have porphyria. Porphyria is the name for a group of genetic diseases in which your body does not make an important component of red blood cells, called heme. Common symptoms of a porphyria “attack,” or episode, include abdominal pain and pain with urination; a rapid heartbeat is also common. If you have porphyria, certain drugs, such as primidone, can trigger a porphyria episode, which can be dangerous—even life-threatening—so it is very important to avoid primidone if you know that you have porphyria.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.