Is divalproex safe for treating migraine?

Steven A. Meyers, MD
Diagnostic Radiology
Divalproex is a generally safe and well tolerated medication for preventing migraine headaches. It is also used to prevent seizures and in certain mood disorders. Most side effects are mild and can be managed with dose adjustments. Common side effects include sedation, nausea, dizziness, tremor, weight gain, and thinning of the hair. Divalproex can rarely cause more serious problems such as liver injury, electrolyte imbalances, and bone marrow suppression. Persons taking divalproex do need to be monitored by a physician and periodic blood testing may be necessary.
Divalproex has been around for many years and is indicated for migraine prevention. Many patients tolerate it well. The falls are dangerous to you and the neurologist will be monitoring you on this drug. It is important to discuss the benefits (hopefully less falls and migraines) versus the risks of the medication (the side effects) with your physician.

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