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What are the side effects of sulfamethoxazole and trimethoprim?

Sulfamethoxazole and trimethoprim treatment may cause a number of side effects. Call 911 if you experience signs of an allergic reaction, including hives, skin rash or swelling of the face, tongue or throat. Also, tell your doctor if you experience any of the following severe side effects: easy bruising or bleeding, pale skin, watery or bloody diarrhea, slow or weak heart rate, severe fatigue or weakness, nausea or loss of appetite, clay-colored stools, dark or discolored urine, infrequent urination, yellowing of the skin or whites of the eyes (jaundice), signs of an infection, such as fever or sore throat, confusion, irritability, hallucinations, seizures or shortness of breath. You may experience side effects that do not require medical attention unless they worsen or last for a long time. These include: dizziness or ringing of the ears, painful or swollen tongue, joint pain or difficulty sleeping. Talk to your doctor if you have any disturbing side effects or ones that are not included on this list.  

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.