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Who should take isoniazid, pyrazinamide, and rifampin?

Every person with active Mycobacterium tuberculosis infection should take two or more antitubercular drugs with different mechanisms of action for at least six months. The combination of isoniazid-pyrazinamide-rifampin (Rifater) is a good choice for your doctor to prescribe since it combines three antitubercular agents in one tablet.

Active TB infection can be so easily passed from one person to another, and so many of the strains are widely resistant to single drug therapy that every person with active infection MUST be treated with multiple-drug therapy.

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