How does Rifater interact with other medications or food?

Rifater is the combination of isoniazid-pyrazinamide-rifampin, a combination drug prescribed to treat tuberculosis (TB). It can boost your risk for side effects from certain other drugs or make them less effective, including:

  • antacids
  • anticonvulsants
  • barbiturates
  • blood pressure medications
  • blood thinners
  • chloramphenicol
  • ciprofloxacin
  • clofibrate
  • cotrimoxazole
  • cycloserine
  • cyclosporine
  • dapsone
  • diabetes medicines
  • disulfiram
  • fluconazole
  • haloperidol
  • heart medicines
  • itraconazole
  • ketoconazole
  • lapatinib or other tyrosine kinase receptor inhibitors
  • levodopa
  • narcotic painkillers
  • nortriptyline
  • probenecid
  • progestins
  • ranolazine
  • steroids
  • sulfasalazine
  • temsirolimus
  • theophylline
  • tranquilizers
  • voriconazole

Isoniazid-pyrazinamide-rifampin can also interact with some foods, including histamine-rich foods, such as tuna, skipjack and tropical fish. You may feel flushed or sweaty, get a headache or experience low blood pressure or irregular heartbeat. It also interacts with tyramine-rich foods, including:

  • aged cheeses
  • avocados
  • bananas
  • beer
  • raisins
  • red wine
  • some sausages and meats (including liver)
  • sour cream
  • soy sauce

Serious high blood pressure can result. When taken while using alcohol, isoniazid-pyrazinamide-rifampin may raise your risk for developing liver problems. Other foods and drugs may pose problems if you take this medication. Make sure your doctor knows about all of the medicines you take.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.