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How does isoniazid-rifampin react with other drugs or foods?

Isoniazid-rifampin (Rifater), a combination drug prescribed to treat tuberculosis (TB), can boost your risk for side effects from certain other drugs or make them less effective, including antacids; anticonvulsants; barbiturates; blood pressure medications; blood thinners; chloramphenicol; ciprofloxacin; clofibrate; cotrimoxazole; cycloserine; cyclosporine; dapsone; diabetes medicines; disulfiram; fluconazole; haloperidol; heart medicines; itraconazole; ketoconazole; lapatinib or other tyrosine kinase receptor inhibitors; levodopa; narcotic painkillers; nortriptyline; probenecid; progestins; ranolazine; steroids; sulfasalazine; temsirolimus; theophylline; tranquilizers; and voriconazole. Isoniazid-rifampin can also interact with some foods, including histamine-rich foods, such as tuna, skipjack and tropical fish. You may feel flushed or sweaty, get a headache or experience low blood pressure or irregular heartbeat. It also interacts with tyramine-rich foods, including aged cheeses, avocados, bananas, beer, raisins, red wine, some sausages and meats (including liver), sour cream and soy sauce. Serious high blood pressure can result. When taken while using alcohol, isoniazid-rifampin may raise your risk for developing liver problems. Other foods and drugs may pose problems if you take this medication. Make sure your doctor knows about all of the medicines you take.

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