Are there any risks in taking Crixivan?

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While taking Crixivan people often develop kidney stones. Hemolytic anemia (the destruction of red blood cells), hepatitis (liver inflammation) and nephrolithiasis/urolithiasis can all occur as a result of taking Crixivan. In some cases, protease inhibitors like Crixivan have been known to cause bleeding, so if you have hemophilia (or any other serious health conditions), be sure to discuss them with your doctor. Crixivan also can affect your blood sugar, which may put people with diabetes at risk for hyperglycemia. While Crixivan may have a negative effect on a pregnant woman, a fetus or a nursing infant, studies are inconclusive about the exact risks, so speak with your physician if you are pregnant, breastfeeding or if you plan to become pregnant. There also have been reports that this medication can cause a redistribution of fat in your body, causing unusual lumps. Crixivan may cause dormant infections in your body to become active as your immune system becomes stronger. Be on the alert for any signs of a developing infection. Since Crixivan can interact with many different medications, check with your doctor to make sure it is safe for you. And, as with any medication, be sure to take Crixivan exactly as prescribed by your physician to avoid the risk of serious complications.

First, be sure to discuss with your doctor any allergies you have, especially to indinavir or other medications.  Provide your doctor and pharmacist with a complete list of prescription and non-prescription medications, vitamins and herbal products (especially St. Johns wort) you are taking.  Crixivan requires precise dosing every 8 hours and has restrictions on what foods can be eaten concurrently.
Side effects associated with Crixivan include:
  • mild nausea, vomiting, diarrhea
  • numbness or tingling around the mouth
  • feeling very tired
  • headache or mood changes
  • change in the distribution of body fat (lipodystrophy)
Contact your doctor immediately if you experience any of the following symptoms:
  • kidney stones or kidney failure
  • metabolic abnormalities including hyperlipidemia (elevated cholesterol levels)
  • back pain or pains in the side of your body
  • hematuria (blood in urine) or dark yellow or brown urine
  • fever, sore throat, headache accompanied by a severe rash which blisters and peels
  • muscle pain
  • excessive tiredness
  • unusual bleeding or bruising
  • flu-like symptoms or signs of a new infection
  • yellowing of the skin or eyes
  • paleness
Crixivan can increase your blood sugar levels.  Again, contact your doctor immediately if you experience any of the following symptoms:
  • frequent urination
  • increased thirst
  • weakness, dizziness or headache