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Is Tylenol (acetaminophen) safe in high doses?

Dr. David L. Katz, MD, MPH
Preventive Medicine
At very high doses, or in people with underlying liver disease, acetaminophen has the potential for liver toxicity. This is perhaps why an FDA advisory committee recommended in 2009 that the maximum adult dose of acetaminophen be reduced from 1,000 mg to 650mg at one time, and that the total daily maximum be reduced from 4 g to 2.6 g.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.