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Can Aceon interact with other medications?

The blood pressure medication Aceon (perindopril) interacts with the following substances:
  • diuretics (water pills). Many people take a water pill along with Aceon to control blood pressure. If you're taking both, your doctor will probably monitor you closely because your blood pressure may drop too low at first. In some cases, you can prevent this by stopping the diuretic or taking a lower dose (with your doctor’s okay), or by eating salt before your first Aceon dose.
  • potassium. If you take Aceon along with potassium supplements or certain other drugs, your blood potassium level may become too high, putting you at risk for potentially deadly heart problems. These medications include spironolactone, amiloride and triamterene, as well as indomethacin, aliskiren, heparin and cyclosporine. If you’re taking any of these drugs in combination with Aceon your doctor should frequently check your potassium level. People with kidney disease or diabetes are at added risk of developing this problem.
  • gold. In rare cases, people treated with both injectable gold (sodium aurothiomalate) and angiotensin-converting enzyme (ACE) inhibitors like Aceon have experienced side effects that include facial flushing, nausea, vomiting and low blood pressure.
  • lithium. There are reported cases of people experiencing overdose symptoms from the bipolar medication lithium after taking it with an ACE inhibitor like Aceon. People who also take a diuretic may be at added risk. If you use both Aceon and lithium, your doctor should monitor you regularly.
  • nonsteroidal anti-inflammatory drugs (NSAIDs). Taking Aceon along with an NSAID can lower Aceon's effectiveness and also interfere with kidney function in a way that could lead to kidney failure. NSAIDs include the pain medications ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn) as well as celecoxib (Celebrex). The elderly, people who already have a kidney condition and those who are taking a diuretic (or whose fluid levels are otherwise low) are at increased risk. Before you have surgery, make sure your surgeon and the anesthesiologist both know that you're taking Aceon plus an NSAID.
  • anesthesia. Some forms of surgical anesthesia cause blood pressure to drop. In combination with Aceon, they could cause your pressure to become too low. Before your procedure, make sure the surgeon and anesthesiologist are aware that you take Aceon before you get anesthesia.
  • other similar drugs. Aceon should generally not be taken with other drugs that work in the same way, including ACE inhibitors and angiotensin receptor blockers (ARBs). Studies have shown that there is no benefit from taking more than one of these drugs, but the risk of adverse effects is higher. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.