How are polyps linked to colon cancer?

Learn about these growths that can sometimes lead to cancer. Plus, tips on preventing and screening for colon cancer.

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Updated on November 20, 2024.

About half of adults over age 50 will get colon polyps, or noncancerous growths in the rectum or colon. According to the American Cancer Society, about 10 percent of these polyps will go on to become cancerous—affecting about one in 25 people in the United States. But research has shown that your odds may be lowered if you exercise regularly.

Any activity will help. Take a brisk stroll, pull weeds, or chase your grandchild around in the yard. And it doesn’t matter what age you are—research shows that being active can reduce your risk of colon cancer no matter how young or old you are.

Polyps and their connection to colon cancer

Polyps are small growths in the lining of the colon or rectum. They form from irregular cells, but they’re usually not dangerous, and they can be pretty common the older a person gets. Polyps don’t always develop into cancer. If they do, they’re usually slow to progress. Once a pre-cancerous polyp has grown big enough to be seen during an examination, they generally take about 10 to 15 years to become cancerous.

If a person is regularly screened, most polyps can be identified and surgically removed. Most people should begin screening at age 45. Certain groups are more at risk, including older people and African Americans. If you have a family history of colon cancer, you are also at higher risk.

Protection from polyps

While you can’t change your age, your race, or your family history, you may be able to lower some of your risk factors for colon cancer by making lifestyle changes. These changes include eating a healthy diet, avoiding alcohol, quitting smoking, and maintaining a healthy weight. One of the biggest changes you can make is to become active.

According to the American Cancer Society, regular moderate to vigorous activity can lower your risk of colon cancer, and the more the better—people who exercise for more time each week, and/or more vigorously, may lower their risk even further.

A 2022 review published in the journal Cancer Cell International looked at the available research linking exercise and colorectal (colon and rectal) cancer prevention. Researchers found that a great number of clinical trials have now shown that exercise can lower colorectal cancer risk.

They found that staying regularly active can lower the risk of cancer by 23–24 percent. Regular vigorous exercise may lower it even more, by 26 percent. And by contrast, being sedentary, or spending most of the time sitting, can raise the risk of colorectal cancer by 30 percent, though this may also be combined with other risk factors like an unhealthy diet and inflammation.

Exercise has tons of benefits. In addition to helping prevent colon cancer, exercise can improve your health in almost every other way, including serving as protection against many other types of cancers. And the research suggests that if you do develop colon cancer and need treatment, regular exercise can help you significantly raise your quality of life, both during and after the cancer treatment. It may help prevent the cancer from recurring, too.

More exercise is better

To boost your overall health and fitness, the Centers for Disease Control and Prevention (CDC) advises getting 150 minutes of moderate-intensity exercise each week. They also advise doing muscle-strengthening exercises twice a week, making sure to work on each of your muscle groups, like your arms, legs, back, abdomen, and chest.

Going beyond these recommendations can bring even more health benefits. But if you're short on time, it's important to know that even a little exercise is worthwhile and will bring real health benefits.

Why exercise helps

The review authors also looked at why exercise seems to be so beneficial. They found evidence that exercise may help to lower inflammation, which has been linked to cancer. Physical activity may also affect insulin as well as leptin and ghrelin, two weight-related hormones, in a way that helps inhibit colon cancer growth. Plus, exercise boosts immune-system function, which may help the body fight off early cancerous cells.

A healthy lifestyle for colon cancer prevention

Here are a few more ways to reduce your colon cancer risk:

  • Eat a high-fiber, low-fat diet. Choose lots of veggies, fruits, and whole grains, and steer clear of processed meats like hot dogs or lunch meats. Try to lower your consumption of ultra-processed foods and red meat (like lamb, beef, or pork).
  • Don't smoke. People who smoke for a long time are more likely to get colon cancer and more likely to die from it, compared to people who don’t smoke. If you need help quitting, ask your healthcare professional (HCP) for resources.
  • Maintain a healthy weight. Having overweight or obesity can raise your chances of developing colon cancer. It also raises your chances of dying from it. Choosing healthier foods and getting regular exercise will help you reach and maintain a healthy weight.
  • Avoid alcohol, which has been found to raise the risk of colorectal cancers. It’s best not to drink any alcohol. If you do choose to drink alcohol, men should have no more than two drinks per day and women should have no more than one. As a reminder, one drink means five ounces of wine, 12 ounces of beer, or 1.5 ounces of hard liquor. 

Finally, it’s important to get screened for colon cancer. The American Cancer Society recommends that adults with average risk factors start getting screened at age 45.

Types of screening tests

There are a number of different options for tests that can find cancers early, before they start causing symptoms and before they’ve spread.  

Some tests look at your stool (poop) to see if there are any signs of blood or antibodies linked to cancer, and these can be done once a year. Another stool test looks for changed DNA in the stool, and this can be done every three years.

The flexible sigmoidoscopy is when an HCP checks for polyps in the rectum and the last third of the colon. It’s usually a screening given every five years. The colonoscopy is the preferred screening test. It’s similar, but the HCP checks the entire length of the colon. Usually this is only done once every 10 years.

There’s even a type of colonoscopy that’s entirely virtual, using computers and X-rays. Talk with your HCP about your personal risk factors and about your preferences to determine which tests you choose and how often you get screened.

Article sources open article sources

Oruç Z, Kaplan MA. Effect of exercise on colorectal cancer prevention and treatment. World J Gastrointest Oncol. 2019 May 15;11(5):348-366.
American Cancer Society. Colorectal Cancer Facts & Figures 2020-2022. PDF accessed May 13, 2024.
American Cancer Society. Six Ways to Lower Your Risk for Colorectal Cancer. February 5, 2021.
Amirsasan R, Akbarzadeh M, Akbarzadeh S. Exercise and colorectal cancer: prevention and molecular mechanisms. Cancer Cell Int. 2022 Aug 9;22(1):247. 
Mount Sinai. Colorectal polyps. Page accessed May 13, 2024.
American Cancer Society. Can Colorectal Cancer Be Prevented? Page last updated March 4, 2024.
Mayo Clinic. Reducing your risk for colorectal cancer. March 13, 2023.
Centers for Disease Control and Prevention. Adult activity: An Overview. Page last accessed November 13, 2024.
Centers for Disease Control and Prevention. Screening for Colorectal Cancer. Page last accessed November 13, 2024.
Colon Cancer Foundation. Ultra-Processed Foods a Risk Factor for Colorectal Cancer. Page last accessed November 13, 2024.

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