What Increases My Risk for Endometrial (Uterine) Cancer?

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Endometrial cancer is ofcourse the number one gynecologic cancer in this country and there are a number of risk factors. One of the big one of course obesity and that is one of the reasons why the Endometrial cancer risk is increasing in the country is because, so many women are over weight.

And the problem with being over weight is that you make an excessive amount of estrogen which can cause an abnormal build up in the lining of the uterus. And this is kind of the thing for uterine cancer, anything that causes excess estrogen and not progesterone to balance it out, can potentially increase the risk of uterine cancer, so in addition to being over weight we look at women who are taking estrogen for postmenopause and maybe they're not taking a progestin, or they're not taking the right progestin, that's a risk factor.

We know that women who are not ovulating maybe because they're peri-menopausal, maybe because they have some other reason that they're not releasing an egg every month, that's going to put them at increase risk. Women who take Tamoxifen for either prevention or treatment of breast cancer, also can sometimes get an abnormal build up in the lining of the uterus, and then of course there's family history.

While most uterine cancers are not genetic, some are and there's a particular gene mutation, which causes Lynch syndrome, and families that have Lynch syndrome not only have an increased risk of uterine cancer, but also colon cancer, stomach cancer and ovarian cancer.