How Advanced Is Stem Cell Research for Parkinson's?

Read Transcript

Stem cell research's been very promising. In our earlier trials, the one that was published in the England journal of medicine they were using fetal embryonic stem cells which as you have filed ethical concerns. The evidence there was that the field graphs took they worked, they lived and they survived, and in fact the patient's scores got improved.

But, they had little bit problem with fetal cells, there were some contaminated in the graphs. There were some cells like [xx], [xx] cells we don't want in the graphs. And the patients some of them got what we call run away [xx], wiggling to much, moving to well because they were producing to much [xx].

So, [xx] are institute which switch to investigating something called [xx] [xx] cell, where we take a skin cell from you the patient, biopsy it from your skin, devolve it into a stem cell, and then re-evolve it into a dopamine producing neuron, with the idea that at some point with proper IRB and FDA clearance, that we can re-inject those cells back-graft into the donor brain.

That way it will be patient-selective, specific. It's autologous, it's your own tissue. It's not some other human organism's tissue, and the theory behind that is there will be less chance of rejection, and probably more purity in the graph. We also have a way of measuring how much dopamine those cells produce, and we have a stop gene that can turn them off, if they're producing too much, or we only inject them when we've got them to a stage where they're producing the amount of dopamine we want.