Don Ingber, MD

7 Videos

Read Transcript

You talk to any pharmaceutical company they're desperate right now,  because the drug development model is in crises, essentially what you had cost millions of dollars, to take drugs and years to take drugs, to the development, they have to use annual models which have ethical issues that they don't like using, and there often poor models and they are so poor that very few of the predication hold up in unit so the drugs go through 500 million dollars develpoments owning  in clinical traps.

 And so we think the future is one where rather than taking engineering trying to solve medical problems that we going to leverage biologically designed principles to develop engineering informations.  And that what we call biologically inspired  engineering.  So the mission really is to continue on that path to uncover her nature built and and really the heart of [xx] is leveraging that to basically develop bio inspired materials and devices that would essentially transform health care and so we have a whole program called organs and sheds where drafting techniques from the micro fabrication industry needs to make computer micro chips to make very small micro systems that we can flow fluids through that we line with human cells, and we actually, it's almost like a 3D micro-section or a histological search of an organ that reconstitutes four organ functionality so our first big for principle is what we call the human breathing war knowledge ship, and we essentially have a smart channel that you can pour air or liquid through.

And think of it sort of like a car tunnel to the airport. And halfway across the middle of it, we have a very thin membrane of holes and on the top of it we put human lung cells that warn air suck, and flow air over it and on bottom of that say membrane we put human capillary blood vessels and we flow medium and we actually flow human white blood cells through it.

And then we have it's made of a clear flexible material and we have little side chambers that have sipec suctions[sp?] and the whole deforms, so it breathes, it stretches and relax. It stretches just like your sacs. So it making a small unit, but with simple device we have been able to not only we communicate entire inflammatory response so we have bacteria on the air side white blood cells stick to the capillary side might get through and engulf on the other side and you can watch this on your time it's so important from pharmaceutical because, they just don't screen drugs.

They have to understand mechanisms to get these approved and also to prioritize which is the drug we spend at next 100 million to go all the way with or what if they had problems to work out the problem and find out which drug to put in. That same device we have new work, where we're remodeling diseases we can model pulmonary edema which is when you have fluid on the lung and we get same doses that drugs induce that has a side effect in humans, we get fluid shifting to the air space and get blood clot formation which is exactly what you see in humans, but in humans you don't see that until they die and you do a biopsy.

Here we can see it in real time and we could screen for drugs to see what might prevent it, in fact we are working with pharmaceutical companies and out there we can test drugs and we can surely prevent them.