What Are the Possibilities of a Malaria Vaccine?

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I think the possibilities of having a vaccine are real and obviously having a vaccine would be the Holy Grail, would be the gold standard, would be the one tool that will really allow us to attempt to eradicate plasmodium farcipram at least, one of the four or five human malarias that are out there.

However, to be honest, there hasn't been a vaccine to date with operational impact that has really made a difference out there. There's been some promising developments on vaccines that show limited protection, and perhaps those might be deployed to reduce severe disease especially in children who are most vulnerable to this parasite, but the parasite has had a very long time to evolve mechanisms to evade the host immune system and so vaccines have an enormous challenge.

A vaccine must produce resistance that's even greater than what can be naturally acquired by being infected multiple times. That's a tall order. I'm not saying that it can't be done, but that is a much longer and more complicated goal than producing for a example a new drug, for which many new drugs have been produced over time, and that have saved millions of lives.