What Do Blood Vessels Have to Do with Migraines?

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Well, what we've learnt is that migraine is a disease of the brain, and has to do with the physiology of the brain, not the structure of the brain. You can image it. You won't see anything wrong, but the physiology of the brain, and blood vessels do change size, but that's only part of the migraine cascade, and that is no longer the center of our universe.

So our treatments shouldn't be directed towards simply constricting or dampening arteries. Those treatments were probably less safe, and companies were trying to develop more and more powerful constrictors over time. Thank goodness that never really panned out because we probably would have had less effective, and probably less safe medication at this point.