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Do naltrexone and bupropion interact with other drugs?

Donna Hill Howes, RN
Family Practitioner

If you are taking bupropion, you should not take Contrave.

If you are taking an opioid, you should not take Contrave.

If you are taking amantadine, carbamazepine, efavirenz, levodopa, phenobarbital, phenytoin, or a protease inhibitor, Contrave may not be a good option for you.

You should not take Contrave while taking an MAO inhibitor or until at least 2 weeks after stopping MAO inhibitors.

If you have stopped drinking alcohol, taking a barbiturate, a benzodiazepine, an anticonvulsant, or an opioid in the past few weeks, you should not take Contrave. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.