What are benefits of taking relatively high doses of vitamin D?

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Leopold D. Galland, MD
Internal Medicine
Some placebo-controlled clinical trials have demonstrated benefits with high dose supplementation of vitamin D that have not been seen with lower doses used in other studies:
  • A Japanese study found that children taking 1200 IU/day had a decrease in influenza during the winter.
  • A New Zealand study found that 4000 IU/day reduced insulin resistance (a precursor of diabetes) in Asian women, and the effect only occurred if the blood level of vitamin D rose to 32 nanograms per milliliter.
  • A Norwegian study found that 20,000 to 40,000 IU/week given for one year reduced depression scores in overweight individuals.
  • A clinical trial done at Creighton University in Nebraska found a 75% reduction in the incidence of cancer among post-menopausal women given 1100 IU vitamin D per day for 4 years. The effect required blood levels greater than 32.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.