What are the side effects of pyridoxine?

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Users of pyridoxine generally experience few or minor side effects. These minor side effects include: nausea, vomiting, abdominal pain, loss of appetite and headaches. However, if you experience numbness or decreased sensations, decreased coordination, staggering or stumbling, fatigue or uncoordinated hands, talk to your doctor. Larger doses are more likely to cause these effects, particularly numbness and a lack of coordination or clumsiness. Allergic reactions are possible. If you notice swelling, hives or closing of the throat, or have a hard time breathing, stop taking pyridoxine and seek emergency medical treatment.