How does pyridoxine interact with other medications or foods?

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Pyridoxine, or vitamin B6, may interact with the cancer drug, altretamine, as well as alcohol and tobacco. Vitamin B6 may also decrease the effectiveness of levodopa, which is used to treat Parkinson's disease. However, the drug carbidopa can prevent this interaction from occurring. Vitamin B6 supplements can also interact with the anti-seizure medications Dilantin and phenobarbital, and the heart medication Cordarone. Because vitamin B6 may already be in other combination B vitamins or multivitamins, you should talk to your doctor before taking a separate pyridoxine supplement since it's possible to overdose on B6. Tell your doctor all the medications, including prescriptions, over-the-counter medications, vitamins and supplements, that you are taking before starting pyridoxine or any other therapeutic treatment.