Can I overdose on pyridoxine?

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It is possible to overdose on vitamin B6 (pyridoxine). Vitamin B6 is present in a variety of foods, which is how most people get their daily requirement. B6 may also be present in other combination B vitamins or multivitamins. Taking any of these in combination with pyridoxine may lead to overdose. Symptoms of overdose include: poor coordination, stumbling or staggering, numbness, fatigue or decreased sensations that can last for up to six months. Seek medical attention if you believe you have taken too much vitamin B6.