What are the vasculitis disorders that can cause neurological symptoms?


Both peripheral and central nervous systems can be involved in several systemic vasculitis, such as lupus, polyarthritis nodosa, Wegener's granulomatosis, Takayasu's arteritis, giant cell arteritis and Behcet's disease, Churg-Strauss syndrome and microscopic polyangiitis. In all of these conditions, the systemic inflammatory process involving the blood vessels has results in central and peripheral nervous systems symptoms, such as mental status changes, seizures, weakness, pain and numbness in the limbs, vision loss and headaches.

Vasculitis syndromes that can cause neurological disorders are follows:

  • Kawasaki disease, which can cause stroke or encephalopathy in children
  • Churg-Strauss syndrome Wegener's granulomatosis
  • Systemic lupus erythematosus
  • Scleroderma
  • Rheumatoid arthritis
  • Sjogren's syndrome
  • Behcet's disease

This answer is based on source information from the National Institute of Neurological Disorders and Stroke.

Nervous system vasculitis can develop as part of an infection, a generalized autoimmune disease such as lupus, Sjögren's syndrome, or with a systemic vasculitis that affects other parts of the body (Wegener's granulomatosis, polyarteritis nodosa); in these cases it is called secondary vasculitis. If vasculitis of the brain or spinal cord develops when no other condition is present, it is called primary central nervous system vasculitis or primary angiitis of the central nervous system (PACNS).

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