A brief episode of confusion was reported in one patient during use of valerian with loperamide (Imodium®) and St. John's wort (Hypericum perforatum L.). Nausea, sweating, muscle cramping, weakness, elevated pulse, and high blood pressure were reported after a single dose of a combination product with St. John's wort, kava, and valerian. Valerian may interact with certain herbs and supplements that are metabolized by the liver.
Based on secondary sources, valerian may have antispasmodic properties.
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